Early nutrition programming with an emphasis on molecular mechanisms of developmental origins of chronic diseases in offspring. While genetic factors, lifestyles, and environment have all been cited as important components of developmental diseases, increasing evidence suggest that maternal factors–especially those that occur in utero and during early postnatal life–also play a significant role in disease development. The long-term goal of my laboratory is to understand the underlying molecular mechanisms by which maternal dietary factors influence the risk of diseases in later life, in order that effective interventions can be developed to reduce the incidence of the disease. We utilize a variety of animal models of human developmental diseases, including obesity, diabetes and cancer. People in my laboratory working on these animal models will also use a wide range of molecular biology techniques including analysis of chromatin structure, promoter analysis, gene delivery, quantitative real-time PCR, sequencing analysis and bioluminescent imaging.