Most people are familiar with the message that reducing intake of saturated and trans fat can improve health. However, there are some types of fats, called essential fatty acids that must be consumed in the diet. Essential fatty acids and their metabolic products exert a variety of physiologic functions in our body, including inflammation, reproduction and regulation of lipid metabolism. Dr. Nakamura’s laboratory created a gene knockout mouse to investigate functions of the essential fatty acids, which is a current focus of research activity in his laboratory.The increasing incidence of obesity worldwide is a significant public health concern, which brings an opportunity and responsibility to the nutrition research community. To address this challenge, his laboratory has been investigating how our body can adapt to diets with varying composition of carbohydrates, fats and proteins. Understanding biochemical and molecular mechanism of metabolic adaptation will provide a basis for dietary prevention of obesity. In addition to this basic research, his laboratory has been developing a new nutrition information delivery system for prevention and treatment of obesity.