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Maternal protein deficiency during pregnancy ‘memorized’ by fetal muscle cells

Editor’s notes: To reach Huan Wang, call 217-417-8655; email

To reach Yuan-Xiang Pan, call 217-333-3466; email

The paper “Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to maternal nutrition” is available online or from the News Bureau.

Original article by Sharita Forrest, Illinois News Bureau, on 9/18/15:

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Pregnancy Nutrition and Health Outcomes | ANHI Conference Summary

Pregnancy Nutrition and Health Outcomes | ANHI Conference Summary.

Please see above link for video of Prof. Yuan-Xiang Pan discussing “The Role of the Placenta in Early Programming” at the 112th Abbott Nutrition Research Conference,  July 26 – July 28, 2011 , Columbus, Ohio USA.

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Yuan-Xiang Pan

Dr. Yuan-Xiang Pan

Early nutrition programming with an emphasis on molecular mechanisms of developmental origins of chronic diseases in offspring. While genetic factors, lifestyles, and environment have all been cited as important components of developmental diseases, increasing evidence suggest that maternal factors–especially those that occur in utero and during early postnatal life–also play a significant role in disease development. The long-term goal of my laboratory is to understand the underlying molecular mechanisms by which maternal dietary factors influence the risk of diseases in later life, in order that effective interventions can be developed to reduce the incidence of the disease. We utilize a variety of animal models of human developmental diseases, including obesity, diabetes and cancer. People in my laboratory working on these animal models will also use a wide range of molecular biology techniques including analysis of chromatin structure, promoter analysis, gene delivery, quantitative real-time PCR, sequencing analysis and bioluminescent imaging.

Associate Professor;; more detail here.


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